SPC
- Director general of police
- IBM SAN Volume Controller
- La Palma Airport
- List of CDMA terminology
- Pacific Community
- Point Code
- SCP (disambiguation)
- SPC Australia
- SPC Group
- SPC file format
- SPC700
- SPOC (disambiguation)
- Saint Paul's College (disambiguation)
- San Pedro College
- San Pedro College of Business Administration
- Scalable Plate Carrier
- Scrabble Players Championship
- Seattle Privacy Coalition
- Secure multiparty computation
- Segregated portfolio company
- Serbian Orthodox Church
- Signal peptidase I
- Signature panel code
- Simple point charge
- Singapore Petroleum Company
- Sisters of Charity of St. Paul
- Smile Precure!
- Social purpose corporation
- Socialist Party of British Columbia
- Socialist Party of Canada
- Sodium percarbonate
- Software Publishing Corporation
- Sony
- Sony Pictures Classics
- South Pacific Championship
- South Park Commons
- South Plains College
- Southern Presbyterian Church (Australia)
- Southwest Preparatory Conference
- Special Purpose Cartridge
- Special police constable
- Special purpose company
- Specialist (rank)
- St Patrick's College (disambiguation)
- St Peter's College (disambiguation)
- St. Petersburg College
- Stage pin connector
- Statistical process control
- Stored program control
- Storm Prediction Center
- Student Police Cadet Project
- Student Price Card
- Summary of Product Characteristics
- Supplementary protection certificate
- Suprapubic catheter
- Supreme People's Court (disambiguation)
- Supreme Petroleum Council (Kuwait)
- Supreme Political Council
- Swedish Paralympic Committee
- Synthetic Plastics Company
- Syrian Petroleum Company
- System Planning Corporation