SPARCL1


SPARC-like protein 1, also known as hevin, is a secreted protein with high structural similarity to SPARC.

Biology

It interacts with the extracellular matrix to create intermediate states of cell adhesion. Due to its dynamic extracellular roles, it is implicated in cancer metastasis and inflammation and it is considered a matricellular protein. In humans hevin is encoded by the SPARCL1 gene. Hevin is produced by astrocytes. It is involved in synapse formation, function, plasticity, and elimination as well as brain chemistry regulation.

Interactions