SMURF2E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome 17q23.3-q24.1.InteractionsSMURF2 has been shown to interact with: Mothers against decapentaplegic homolog 1, Mothers against decapentaplegic homolog 2, Mothers against decapentaplegic homolog 3, Mothers against decapentaplegic homolog 7, SCYE1, SMURF1, and Ubiquitin C. TOP2A,