SMO
- Be More
- Big Smo
- Royal Army Medical Corps
- SQL Server Management Objects
- Sabhal Mòr Ostaig
- Samoa
- Samoan language
- Santa Monica Airport
- Sara Forsberg
- Sequential minimal optimization
- Singapore Mathematical Olympiad
- Site management organization
- Slovak Youth Orchestra
- Smoothened
- Social media optimization
- Social movement organization
- Solar Monitoring Observatory
- South Merton railway station
- Special military operation
- Spermine oxidase
- Styrene monooxygenase
- Super Mario Odyssey