SMC
- .SMC
- Apple SMC
- DO-214
- IEEE Systems, Man, and Cybernetics Society
- Modern Centre Party
- SMC Corporation
- SMC Recordings
- SMC connector
- SMC protein
- Salmaniya Medical Complex
- Samsung Medical Center
- San Miguel Corporation
- Santa Monica College
- Sargodha Medical College
- Satyrs Motorcycle Club
- Science Media Centre
- Scottish Mountaineering Club
- Seasonal malaria chemoprevention
- Seattle Men's Chorus
- Secret Maryo Chronicles
- Secure multi-party computation
- Self-modifying code
- Semarang Poncol railway station
- Senior Military College
- Sequential Monte Carlo method
- Serbia and Montenegro Cup
- Shanghai Municipal Council
- Shaw Multicultural Channel
- Sheet moulding compound
- Shimla Municipal Corporation
- Singapore Mediation Centre
- Single-member district
- Sliding mode control
- Small Magellanic Cloud
- Smooth muscle cell
- Social Marketing Company
- Sound and music computing
- Southern Media Corporation
- Southwestern Michigan College
- Space and Missile Systems Center
- Spartanburg Methodist College
- Speak Mandarin Campaign
- Special Metals Corporation
- St. Michael's College, Iligan City
- Stade Malherbe Caen
- Standard Microsystems Corporation
- Stanley Medical College
- Stewart's Melville College
- Sufi Muslim Council
- Super Mini Comboy
- Supplementary motor cortex
- Supreme Military Council (Ghana)
- Supreme Muslim Council
- Surat Municipal Corporation
- Surface-mount component
- Suzuki Motor Corporation
- Swathanthra Malayalam Computing
- Swiss Management Center
- Symmetric monoidal category
- System Management Controller
- The Singing Machine Company
- United Kingdom Mathematics Trust