SMAC
- FBi SMAC Awards
- Sabang Merauke Raya Air Charter
- Sarah McCreanor
- Second mitochondria-derived activator of caspases
- Sequential Multiple Analysis - Computer
- Sid Meier's Alpha Centauri
- Smack (disambiguation)
- Social Mobile Analytics Cloud
- Southern Maryland Athletic Conference
- Southwestern Michigan Athletic Conference
- Stone Mountain Arts Center
- Supramolecular activation cluster
- Supreme Macedonian-Adrianople Committee