SLC25A51

Solute carrier family 25 member 51, also known as SLC25A51 and MCART1, is a protein which in humans is encoded by the SLC25A51 gene. This gene encodes a mitochondrial NAD⁺ transporter and is a member of the mitochondrial carrier family of solute carrier proteins.

Structure

The SLC25A51 gene is located on the p arm of chromosome 9 in position 13.2 and spans 24,954 base pairs. The gene produces a 33.7 kDa protein composed of 297 amino acids. This gene has 6 exons and encodes a multi-pass integral membrane protein localized to the mitochondrial inner membrane.

Function

The product of this gene is essential for the import of NAD⁺ into the mitochondria.

Clinical significance

Diseases associated with this gene include urea cycle disorders.