SKF-39315
SKF-39315 is a monoamine receptor modulator of the 3-benzazepine family. It is a cyclized phenethylamine analogue of the neurotransmitter dopamine. The drug shows affinities of 12nM for the dopamine D2 receptor and 5,200nM for the dopamine D1 receptor. It also has direct and indirect adrenergic actions. The 1-phenyl derivative of SKF-39315 is SKF-38393, which has reversed activities at dopamine receptors compared to SKF-39315 and acts as a selective dopamine D1-like receptor agonist. SKF-39315 was first described in the scientific literature by at least 1988.