SHS
- Jesse O. Sanderson High School
- Jingzhou Shashi Airport
- Kingdom of SHS
- Marvel Super Hero Squad (video game)
- Merrydown
- Muncie Southside High School
- Pittsford Sutherland High School
- SHS (football club)
- SHS International
- Sackville High School
- Sacred Heart National Secondary School
- Sacred Heart School (Bahrain)
- Safford High School
- Sagano High School
- Sahuaro High School
- Salem High School (disambiguation)
- Salida High School
- Saline High School (disambiguation)
- Salisbury High School (disambiguation)
- Sammamish High School
- Sanderson High School, East Kilbride
- Sandusky High School
- Sanford High School
- Sarah Huckabee Sanders
- Saraland High School
- Sattari High School
- Saugus High School (California)
- Scarsdale High School
- Schaumburg High School
- School-Home Support
- Scottish History Society
- Seagoville High School
- Seaholm High School
- Seaman High School
- Sebeka High School
- Secondhand smoke
- Secure Hash Standard
- Seekonk High School
- Sehome High School
- Selby High School
- Self-propagating high-temperature synthesis
- Selwyn House School
- Seminole High School (disambiguation)
- Senn High School
- Service High School
- Seven Hills School
- Sewanhaka High School
- Shanghai High School
- Sharyland High School
- Shaw High School (disambiguation)
- Shawnee High School (disambiguation)
- Sheffield High School, South Yorkshire
- Sheldon High School (disambiguation)
- Shell Scrap Object File
- Shepparton High School
- Sherando High School
- Sherburn High School
- Sherwood High School (disambiguation)
- Sheung Shui station
- Shiv Sena (1966–2022)
- Shortridge High School
- Shrewsbury High School, Shropshire
- Silverado High School (disambiguation)
- Sitka High School
- Skyline High School (disambiguation)
- Skyridge High School
- Skyview High School (disambiguation)
- Snohomish High School
- Socialist History Society
- Society for Health Systems
- Socorro High School (disambiguation)
- Soldotna High School
- Somerville High School (disambiguation)
- Souhegan High School
- Southaven High School
- Southborough High School
- Southmoore High School
- Southridge High School (disambiguation)
- Southside High School (disambiguation)
- Southwood High School
- Spaulding High School (disambiguation)
- Spencerport High School
- Springboro High School
- Springbrook High School
- Springfield High School (disambiguation)
- Springhill High School, Rochdale
- Springville High School (disambiguation)
- Stafford High School (Stafford, Texas)
- Stafford Senior High School
- Stamford High School (Stamford, Connecticut)
- Stansbury High School
- Stanwood High School
- Staples High School
- Statesboro High School
- Steinbrenner High School
- Stephanie Herseth Sandlin
- Sterling High School (disambiguation)
- Stevens High School (disambiguation)
- Stevenson High School (Lincolnshire, Illinois)
- Stourport High School
- Stow-Munroe Falls High School
- Stranahan High School
- Stratford High School (disambiguation)
- Streamwood High School
- Stroud High School
- Structural hollow section
- Structural steel
- Sturgis High School
- Stuttgart High School (Germany)
- Suffern High School
- Sullivan High School
- Sultan Senior High School
- Suncoast Community High School
- Sunderland High School
- Sunnyvale High School
- Sunset High School (Beaverton, Oregon)
- Super Hero Squad
- Superior High School (Wisconsin)
- Sutton High School (disambiguation)
- Suzhou High School
- Swiss Heritage Society
- Sydney Boys High School
- Syosset High School
- The Super Hero Squad Show
- White House Press Secretary
- Yamaha SHS-10