SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene. SGTA orthologs have also been identified in several mammals for which complete genome data are available. STGA belongs to a family of co-chaperone proteins that obtain a TPR motif. STGA was discovered just 15 years ago.
Function
The molecular function of the protein states that SGTA is a small glutamine-rich tetratricopeptide repeat -containing protein, ubiquitously expressed, interacting with the NS1 protein of parvovirus H-1.The SGTA gene encodes a protein that is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.
Overview of main functions:
- hormone signaling
- viral assembly and release
- cell cycle and apoptosis
- intracellular compartmentalization
- neuronal synaptic transmission
- post-translational transport and modification of proteins.
Interactions
SGTA has been shown to interact with Growth hormone receptor.Interacting Proteins for the SGTA Gene:
Source:
- Prostate, ovary, liver, and esophagus cancer
- Hormone-related polycystic ovary syndrome
- Amyloid-related Alzheimer's
- Prion Diseases