Shugoshin 2Shugoshin 2 '', also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.FunctionShugoshin-2 is one of the two mammalian orthologs of the Shugoshin/Mei-S322 family of proteins that regulate sister chromatid cohesion by protecting the integrity of a multiprotein complex named cohesin. This protective system is essential for faithful chromosome segregation during mitosis and meiosis, which is the physical basis of Mendelian inheritance.