SGCAAlpha-sarcoglycan is a protein that in humans is encoded by the SGCA gene.FunctionThe dystrophin-glycoprotein complex comprises a group of proteins that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Components of the DGC include dystrophin, which is deficient in Duchenne muscular dystrophy ; syntrophins ; dystroglycans ; and sarcoglycans, such as adhalin, a 50-kD transmembrane protein..Clinical significanceMutations in the SGCA gene are known to cause Limb-girdle muscular dystrophy, autosomal recessive 3. This condition causes progressive muscle wasting from early childhood leading to loss of independent mobility as a teenager.InteractionsSGCA has been shown to interact with Biglycan.