SFE
- Australian Securities Exchange
- OpenIndiana
- Sales force effectiveness
- San Fernando Airport (Philippines)
- Scottish Financial Enterprise
- Scouts for Equality
- Secure function evaluation
- Shannon-Fano-Elias coding
- Sigma Phi Epsilon
- Solar flare effect
- SparkFun Electronics
- Stacking-fault energy
- Student Loans Company
- Supercritical fluid extraction
- Supplier-furnished equipment
- Surface energy
- The Encyclopedia of Science Fiction