SDZ SER-082

SER-082, or SDZ SER-082, is a selective serotonin 5-HT_2B and 5-HT_2C receptor antagonist or weak partial agonist with an ergoline-like structure which is used in scientific research. It shows similar affinity for the serotonin 5-HT_2B and 5-HT_2C receptors and has ~40-fold higher affinity for the serotonin 5-HT_2C receptor over the closely related serotonin 5-HT_2A receptor.
It has been used in animal studies into the behavioural effects of the different 5-HT₂ subtypes, and how they influence the effects of other drugs such as cocaine. The drug has been found to have no effect on anxiety in multiple paradigms in rodents. In contrast to other serotonin 5-HT_2C receptor antagonists, SER-082 does not produce hyperlocomotion in rodents, and instead can produce hypolocomotion at high doses that is independent of the serotonin 5-HT_2C receptor.
It fails to block the effects of serotonergic psychedelics in multiple behavioral paradigms, in contrast to serotonin 5-HT_2A receptor antagonists. However, the hypolocomotion induced by high doses of the phenethylamine psychedelic DOI can be attenuated by SER-082. Conversely, the drug was ineffective against the hypolocomotion induced by the tryptamine psychedelic 5-MeO-DMT, whereas the serotonin 5-HT_1A receptor antagonist WAY-100635 was effective.