SDC
- IEEE 11073 service-oriented device connectivity
- SAARC Documentation Centre
- Samsung Developer Conference
- San Diego County
- Sassarese language
- Secure Download Cabinet
- Self-driving car
- Sentosa Development Corporation
- Sheffield Development Corporation
- Shoreditch High Street railway station
- Show Dem Camp
- Smart Data Compression
- Societas Doctrinæ Christianæ
- Society of Dyers and Colourists
- Spirit DataCine
- Stage Directors and Choreographers Society
- Statistical disclosure control
- Structured Data on Commons
- Stupid D Compiler
- Sussex Downs College
- Sustainable Development Commission
- Swiss Agency for Development and Cooperation
- Sydney Development Corporation
- Syrian Democratic Council
- System Development Corporation