The highway was established in 1941 or 1942 as a new primary routing traveling from SC 12 to US 21. Between 1948 and 1952, the highway was downgraded to secondary status until entire length was paved. SC 555 was widened to four lanes in phases: SC 12 to SC 16 by 1964, to I-20 by 1970, and finally to I-77 by 1982.