SCS
- Bus SCS
- Carnegie Mellon School of Computer Science
- Civil Service (United Kingdom)
- Civil Services of India
- SBCS
- SCS Software
- Saba Comprehensive School
- Saint Christopher School
- Salisbury, Maryland
- Saraland City Schools
- ScS
- Scatsta Airport
- School of Communication Studies, Panjab University
- Scottish Courts and Tribunals Service
- Sea Control Ship
- Self-contained system (software)
- Shelburne, Vermont
- Shelby County Schools (disambiguation)
- Shopping City Süd
- Sierra Canyon School
- Silvertown Tunnel cycle shuttle
- SimCity Societies
- Simcoe Composite School
- Singapore Children's Society
- Single Channel Simulcast
- Single-crystal silicon
- Smithtown Christian School
- Smooth clean surface
- Social Credit System
- Society for Classical Studies
- Society of Christian Socialists
- Soil Conservation Service
- Someday Came Suddenly
- Sony Creative Software
- South China Sea
- South Crest School
- Southfield Christian School
- Special Collection Service
- Spinal cord stimulator
- St. Catherine of Siena Parish, Wilmington, Delaware
- St. Christopher's School, Harare
- St. Clair Shores, Michigan
- St. Clement's School
- St. Columba's School, Delhi
- St. Crispin's Senior Secondary School
- St. Cuthbert's Society
- Standard Combat Series
- State of Slovenes, Croats and Serbs
- Stevens Cooperative School
- Sumter County School District (disambiguation)
- Super Coppa Sammarinese
- Supply chain security
- Sweet chili sauce
- Synthetic catalytic scavenger
- Syrian Computer Society