SCL
- Arturo Merino Benítez International Airport
- C++
- C++ Standard Library
- CentOS
- ICL VME
- I²C
- NOS/VE
- National Senior Classical League
- SCL Group
- Sculptor (constellation)
- Seaboard Coast Line Railroad
- Seattle City Light
- Security characteristic line
- Semi-Conductor Laboratory
- Sha Tin to Central Link
- Shina language
- Short circuit level
- Silchar railway station
- Skin conductance
- Sleep Convention Logic
- Society of Chief Librarians
- Southeastern Composers League
- Stanford University centers and institutes
- Structured Control Language
- Studies in Canadian Literature
- Substation Configuration Language
- Swiss Challenge League
- Symptom Checklist 90