SC
- .sc
- ACM/IEEE Supercomputing Conference
- Athletics abbreviations
- Bitter SC
- Hong Kong Certificate of Education Examination
- Lexus SC
- List of patrol vessels of the United States Navy
- PC/SC
- SC (complexity)
- SC Paragliding
- SC convoys
- SC radar
- SC2 (disambiguation)
- SCC (disambiguation)
- SCSC (disambiguation)
- SCTV (Indonesia)
- Sacrosanctum Concilium
- Saint Kitts and Nevis
- Santa Catarina (state)
- Santa Cruz, California
- Sardinian language
- Sc (digraph)
- Scandium
- Scheduled Castes
- Schmidt number
- Scientific computation
- Scots College, Wellington
- Secunderabad Railway Station
- Senior Counsel
- Seychelles
- Shandong Airlines
- Sichuan
- Sierra Canyon School
- Sim City
- Simplified Chinese characters
- Snapchat
- Soccer club
- Social club
- Sodium cyanide
- Soulcalibur
- SoundCloud
- South Carolina
- South Carolina Gamecocks
- Southern California
- Southern California Trojans
- Southland College
- Special constable
- Sports club
- SportsCenter
- SportsCentre
- St. Christopher's School, Harare
- Standard Chartered
- Standard Chinese
- Star of Courage (Australia)
- Star of Courage (Canada)
- StarCraft (video game)
- State College
- Statutes of Canada
- Subcutaneous injection
- Submarine chaser
- Superior colliculus
- Supreme Commander (video game)
- Supreme Court
- Switched capacitor
- Unified Soil Classification System
- United Nations Security Council
- University of South Carolina
- University of Southern California
- Windows service
- × Sophrocattleya