SAFE
- SAFE (New Zealand organisation)
- SAFE (Struggle Against Financial Exploitation)
- SAFE (cable system)
- SAFE Act (disambiguation)
- Safe (disambiguation)
- Safe Ireland
- Safe affordable fission engine
- Scaled agile framework
- Simple agreement for future equity (SAFE)
- Society of Aviation and Flight Educators
- State Administration of Foreign Exchange
- Strategic Action For Emergencies
- Stroke Alliance for Europe
- Survivor Activating Factor Enhancement
- Synchronized Armed Forces Europe