S80
- Canon PowerShot S80
- County Route S80 (Bergen County, New Jersey)
- County Route S80 (California)
- Daihatsu Hijet (S80)
- FAW Senya S80
- Idaho County Airport
- S postcode area
- S-80 Plus-class submarine
- S80 Port of Taicang North Port Expressway
- Series 80 (software platform)
- Short S.80
- Sikorsky S-80
- Super 80
- Toyota Crown (S80)
- Vienna S-Bahn
- Volvo S80
- Yamaha S80