List of highways numbered 261
- Alabama State Route 261
- Arizona State Route 261
- Bundesautobahn 261
- California State Route 261
- County Route 261 (Erie County, New York)
- Delaware Route 261
- European route E261
- Farm to Market Road 261
- Florida State Road 261
- Georgia State Route 261
- Indiana State Road 261
- Japan National Route 261
- K-261 (Kansas highway)
- Kentucky Route 261
- Malaysia Federal Route 261
- Maryland Route 261
- Mexican Federal Highway 261
- Milwaukee Road 261
- Minnesota State Highway 261
- New Mexico State Road 261
- New York State Route 261
- North Carolina Highway 261
- Norwegian County Road 261
- Ohio State Route 261
- Oregon Route 238
- Pennsylvania Route 261
- Prince Edward Island Route 261
- Quebec Route 261
- SP-261
- South Carolina Highway 261
- Tennessee State Route 261
- Texas State Highway 261
- Texas State Highway Spur 261
- Utah State Route 261
- Virginia State Route 261
- Washington State Route 261