List of highways numbered 116
- A116 (disambiguation)
- Alabama State Route 116
- Arkansas Highway 116
- Arkansas Highway 116 (1927)
- BR-116
- California State Route 116
- Colorado State Highway 116
- Connecticut Route 116
- County Road 116 (Duval County, Florida)
- County Route 116 (Bergen County, New Jersey)
- County Route 116 (Fulton County, New York)
- County Route 116 (Niagara County, New York)
- County Route 116 (Rensselaer County, New York)
- County Route 116 (Suffolk County, New York)
- County Route 116 (Sullivan County, New York)
- County Route 116A (Fulton County, New York)
- D116 road
- Farm to Market Road 116
- Florida State Road 116
- Georgia State Route 116
- Illinois Route 116
- Indiana State Road 116
- Iowa Highway 116
- K-116 (Kansas highway)
- Louisiana Highway 116
- M-116 (Michigan highway)
- Maine State Route 116
- Maryland Route 116
- Massachusetts Route 116
- Missouri Route 116
- National Highway 116 (India)
- National Route 116 (Costa Rica)
- Nebraska Highway 116
- Nevada State Route 116
- New Brunswick Route 116
- New Hampshire Route 116
- New Mexico State Road 116
- New York State Route 116
- North Carolina Highway 116
- Ohio State Route 116
- Oklahoma State Highway 116
- Pennsylvania Route 116
- Prince Edward Island Route 116
- Puerto Rico Highway 116
- Puerto Rico Highway 116R
- Quebec Route 116
- R116 road (Ireland)
- Rhode Island Route 116
- Route 116 (Japan)
- S116 (Amsterdam)
- South Carolina Highway 116
- South Dakota Highway 116
- Tennessee State Route 116
- Texas State Highway 116
- Texas State Highway Loop 116
- Texas State Highway Spur 116
- U.S. Route 116
- Utah State Route 116
- Vermont Route 116
- Virginia State Route 116
- Virginia State Route 116 (1923-1928)
- Virginia State Route 116 (1928-1930)
- Virginia State Route 116 (1930-1932)
- Washington State Route 116
- Wisconsin Highway 116
- Wyoming Highway 116