Richard Kremer
Richard Kremer FRCPC is a physician-scientist who specializes in Endocrinology and Laboratory Medicine. Kremer is professor of medicine at McGill University in Montreal, Quebec, Canada. He is also a Senior Scientist at the Research Institute of the McGill University Health Centre at its Centre for Translational Biology. Kremer is also Director of the Bone and Mineral Unit and Academic Director at the McGill University Health Centre. and past Co-Director of the Musculoskeletal Axis. Kremer is a full member of the Canadian Institutes of Health Research's College of Reviewers.
Education
Kremer was born in Paris, France, and received his MD and PhD degrees at the Pierre et Marie Curie University of Paris. He then completed his internal medicine and endocrinology residency Pitié-Salpêtrière Hospital in Paris. Kremer later moved to Canada where he completed further residency training in Endocrinology and Laboratory Medicine at the Montreal General, Royal Victoria, and Ottawa Civic Hospitals. He would go on to pursue his research training at the Royal Victoria Hospital where he joined as a full-time physician in 1989.Research work
Research on the Parathyroid Hormone-Related Protein (PTHrP)
Kremer was credited for creating the antibodies that blocked the Parathyroid Hormone-Related Protein in a widely reported study on Pancreatic Cancer. Kremer previously discovered PTHrP's initiating role in Breast Cancer and its progression which could also be blocked by anti-PTHrP antibodies as was reported in 2011. Kremer's research on PTHrP has been impactful and he is considered a top 10 researcher in the field worldwide, having been ranked number 3 worldwide in scholarly output between 2016 and 2021 in the same field.Research on bone
Kremer and colleagues reported that women who use oral bisphosphonates to prevent osteoporosis may also be at lower risk of skeletal complications of breast cancer. Kremer was also part of the Canadian Institute of Health Research's 2009 Final Report on Bone Health.Research on Vitamin D
Kremer has also been involved in research on vitamin D which led to the discovery of a phenomenon known as "vitamin D resistance in cancer." as a consequence of ras-induced phosphorylation of the retinoid X receptor which disrupts its heterodimeric association with the vitamin D receptor. Kremer and his colleague Vicente Gilsanz were the first to report the clear link between vitamin D levels and accumulation of fat in muscle tissue in 2010, which was widely reported as a ground-breaking study. This study by Kremer and colleagues showed the inverse relationship between vitamin D and fat, which demonstrated that people with more fat were also likely to be vitamin D deficient.On a similar line of inquiry, earlier studies by Kremer and colleagues demonstrated the link between a lack of vitamin D and weight gain and stunted growth in girls.