| Ministry | Incumbent |
| President of South Sudan | Salva Kiir Mayardit |
| Vice Presidents of South Sudan | Riek Machar |
| Vice Presidents of South Sudan | Benjamin Bol Mel |
| Vice Presidents of South Sudan | Taban Deng Gai |
| Vice Presidents of South Sudan | Rebecca Nyandeng Manyang |
| Vice Presidents of South Sudan | Josephine Joseph Lagu |
| Minister of Presidential Affairs | Chol Ajongo Mawut |
| Minister of Agriculture and Forestry | Hussein Abdelbagi |
| Minister of Livestock and Fisheries | Onyoti Adigo Nyikec |
| Minister of Cabinet Affairs | Martin Elia Lomuro |
| Minister of Investment | Joseph Mum Majak |
| Minister Youth and Sports | Dr. Joseph Geng Akech |
| Minister of Defence and Veterans Affairs | Chol Thon Balok |
| Minister of East African Affairs | Deng Alor Kuol |
| Minister of Energy and Dams | Peter Mercallo Nasir |
| Minister of Environment and Forestry | Josephine Napwon Cosmas |
| Minister of Federal Affairs | Lasuba Loduro Wango |
| Minister of Finance and Economic Planning | Athian Diing Athian |
| Minister of Foreign Affairs and International Cooperation | Monday Semaya Kumba |
| Minister of Gender and Social Welfare | Ayaa Benjamin Warille |
| Minister of General Education and Instruction | Kuyok Abol Kuyok |
| Minister of Health | Sarah Cleto Rial |
| Minister of Higher Education, Science and Technology | Madut Biar Yel |
| Minister of Land, Housing and Urban Development | Michael Chanjiek Geay |
| Minister of Humanitarian Affairs | Albino Akol Atak |
| Minister of Information, Communication Technology and Postal Services | Michael Makuei Lueth |
| Minister of Interior | Angelina Teny |
| Minister of Water Resources and Irrigation | James Mawich Makuac |
| Minister of Justice and Constitutional Affairs | Wëk Mamer |
| Minister of Labour | James Hoth Mai |
| Minister of Petroleum | Puot Kang Chol |
| Minister of National Security | Obuto Mamur Mete |
| Minister of Parliamentary Affairs | Mary Nawai Martin |
| Minister of Culture, Museums and National Heritage | Nadia Arop Dudi |
| Minister of Peace Building | Stephen Parl Kuol |
| Minister of Public Service and Human Resource Development | Dak Duop Bichiok |
| Ministry of Trade and Industry | Atong Kuol Manyang |
| Minister of Mining | Martin Abucha |
| Minister of Roads and Bridges | Simon Mijok Majak |
| Minister of Transport | Lam Akol Ajawin |
| Minister of Wildlife, Conservation and Tourism | Rizik Zakaria Hassan |
| Ministry | Incumbent |
| President of South Sudan | Salva Kiir Mayardit |
| First Vice President of South Sudan | Taban Deng Gai |
| Vice President of South Sudan | James Wani Igga |
| Minister in the Office of the President | Mayiik Ayii Deng |
| Minister of Agriculture and Forestry | Onyoti Adigo Nyikwec |
| Minister of Animal Resources and Fisheries | James Janka Duku |
| Minister of Cabinet Affairs | Martin Elia Lomuro |
| Minister of Commerce, Industry and Investment | Paul Mayom Akec |
| Minister of Culture, Youth and Sports | Dr. Nadia Arop Dudi |
| Minister of Defence and Veterans Affairs | Gen. Kuol Manyang Juuk |
| Minister of Electricity and Dams | Dr. Dhieu Mathok Diing |
| Minister of Environment | Josephine Napon |
| Minister of Finance and Economic Planning | Salvatore Garang Mabiordit |
| Minister of Foreign Affairs and International Cooperation | Awut Deng Acuil |
| Minister of Gender, Social Welfare and Religious Affairs | Agnes Kwaje Lasuba |
| Minister of General Education and Instruction | Deng Deng Hoc |
| Minister of Health | Dr. Riak Gai Kok |
| Minister of Higher Education, Science and Technology | Yen Oral Lam |
| Minister of Housing, Physical Planning and Environment | Dr Lado Gore |
| Minister of Humanitarian Affairs and Disaster Management | Hussein Maar Nyot |
| Ministry of Information, Communication Technology and Postal Services | Michael Makuei Lueth |
| Minister of Internal Affairs | Micheal Chiengjiek |
| Minister of Irrigation and Water Resources | Sophia Pal Gai |
| Minister of Justice | Paulino Wanawilla |
| Minister of Labour, Public Service and Human Resource Development | James Hoth Mai |
| Minister of National Security | Gen. Obuto Mamur Mete |
| Minister of Parliamentary Affairs | Peter Bashir Bande |
| Minister of Petroleum and Mining | Ezekiel Lul Gatkuoth |
| Minister of Roads and Bridges | Rebecca Joshua Okwaci |
| Minister of Transport and Roads | John Luk Jok |
| Minister of Wildlife Conservation and Tourism | Jemma Nunu Kumba |