Renal glycosuria
Renal glycosuria is a rare condition in which the simple sugar glucose is excreted in the urine despite normal or low blood glucose levels. With normal kidney function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in the blood. However, in those with renal glycosuria, glucose is abnormally elevated in the urine due to improper functioning of the renal tubules, which are primary components of nephrons, the filtering units of the kidneys.
Signs and symptoms
In most affected individuals, the condition causes no apparent symptoms or serious effects. When renal glycosuria occurs as an isolated finding with otherwise normal kidney function, the condition is thought to be inherited as an autosomal recessive trait.Causes
Renal glycosuria can result from Fanconi syndrome or familial renal glucosuria. Familial renal glycosuria is caused by mutations of SLC5A2, which codes for the sodium-glucose cotransporter 2.Additionally, SGLT2 inhibitor medications produce glycosuria as their primary mechanism of action, by inhibiting sodium/glucose cotransporter 2 in the kidneys and thereby interfering with renal glucose reabsorption.