| Route | Name | Type | Traffic direction | # of lanes | Districts | Notes |
| Abad Santos Avenue | Secondary | two-way | 6–8 | Tondo | Road continues south as R. Regente Street |
| Adriatico Street | Tertiary | one-way, two-way | 6 | Ermita and Malate | |
| Ayala Boulevard | Secondary | two-way | 4 | Ermita | |
| Blumentritt Road | Secondary | two-way | 2–4 | Santa Cruz and Sampaloc | |
| Bonifacio Drive | Secondary | two-way | 8 | Port Area, Intramuros, and Ermita | |
| Carlos Palanca Street | Tertiary | one-way, two-way | 4 | Quiapo and San Miguel | |
| Del Pilar Street | Tertiary | one-way | 2 | Ermita and Malate | |
| Dimasalang Street | Secondary | two-way | 4–6 | Santa Cruz and Sampaloc | |
| España Boulevard | Secondary | two-way | 8 | Sampaloc | |
| Escolta Street | Tertiary | one-way | 2 | Binondo | |
| Finance Road | Tertiary | two-way | 6 | Ermita | |
| Hidalgo Street | Tertiary | two-way | 4 | Quiapo | |
| Jose Laurel Street | Tertiary | two-way | 4 | San Miguel | Road continues west as C. Palanca Street |
| Juan Luna Street | Tertiary | one-way, two-way | 4-6 | Binondo and Tondo | |
| Kalaw Avenue | Secondary | two-way | 6 | Ermita | |
| Lacson Avenue | Secondary | two-way | 4–8 | Santa Cruz and Sampaloc | |
| Legarda Street | Secondary | two-way | 4–8 | Quiapo and Sampaloc | |
| Lerma Street | Secondary | two-way | 8 | Sampaloc | |
| Magsaysay Boulevard | Secondary | two-way | 8 | Sampaloc and Santa Mesa | |
| Maria Orosa Street | Tertiary | one-way, two-way | 2 | Ermita and Malate | |
| Mendiola Street | Tertiary | two-way | 4–6 | San Miguel | |
| Nicanor Reyes Street | Tertiary | two-way | 4 | Sampaloc | Formerly known as Morayta Street |
| Ocampo Street | Tertiary | one-way, two-way | 2–4 | Malate and San Andres Bukid | Formerly and still referred to as Vito Cruz Street |
| Osmeña Highway | Secondary | two-way | 10 | Paco, Malate, and San Andres | Road starts at Quirino Avenue |
| Padre Burgos Avenue | Secondary | two-way | 8 | Ermita | Road continues west as Katigbak Parkway, ends at Jones Bridge |
| Padre Faura Street | Tertiary | one-way | 3 | Ermita and Paco | |
| Pascual Casal Street | Secondary | two-way | 4 | San Miguel and Quiapo | |
| Paula Sanchez Street | Secondary | two-way | 2–4 | Santa Mesa | |
| Pedro Gil Street | Tertiary | one-way, two-way | 2 | Ermita, Malate, Paco, and Santa Ana | |
| Quezon Boulevard | Secondary | two-way | 6–10 | Ermita, Quiapo, and Sampaloc | Road continues north as A. Mendoza Street, continues south as Padre Burgos Avenue |
| Quintin Paredes Road | Tertiary | one-way | 4 | Binondo | |
| Quirino Avenue | Secondary | two-way | 4–6 | Malate, Paco and Pandacan | Includes the extension as N156 running from Quirino Avenue to UN Avenue |
| Recto Avenue | Secondary | two-way | 4–6 | Tondo, Binondo, Santa Cruz, and Sampaloc | |
| Rizal Avenue | Secondary | two-way | 2–6 | Santa Cruz and Tondo | |
| Ronquillo Street | Secondary | one-way | 2 | Santa Cruz | |
| Roxas Boulevard | Primary | two-way | 8 | Ermita and Malate | Road continues north as Bonifacio Drive |
| San Andres Street | Tertiary | one-way, two-way | 4 | Malate and San Andres Bukid | |
| San Marcelino Street | Tertiary | one-way | 4 | Malate, Paco, and Ermita | Road starts at Natividad Lopez Street and ends at San Andres Street |
| Taft Avenue | Secondary | two-way | 4–8 | Ermita and Malate | Road continues north as Padre Burgos Avenue |
| Tayuman Street | Secondary | two-way | 4 | Tondo and Santa Cruz | Road starts at Juan Luna Street and ends at Lacson Street |
| Tejeron Street | Tertiary | two-way | 4 | Santa Ana | |
| Tomas Claudio Street | Secondary | one-way, two way | 2–4 | Paco, Pandacan, Santa Mesa | Road starts from Quirino Avenue. Part of the Nagtahan Link Bridge |
| United Nations Avenue | Secondary | two-way | 4–6 | Ermita and Paco | Road starts at Roxas Boulevard and continues as Paz Mendoza Guazon Street |
| Valenzuela Street | Secondary | one-way | 2–3 | Santa Mesa | Road starts at Magsaysay Boulevard and continues as P. Sanchez Street |
| Victorino Mapa Street | Secondary | one-way, two-way | 4–6 | Santa Mesa | Road starts at Magsaysay Boulevard and continues as P. Sanchez Street |
| Zobel Roxas Street | Tertiary | one-way, two-way | 2–4 | Malate, San Andres Bukid, and Santa Ana | Road starts at F. Muñoz Street and continues as R. Delpan Street |
| Route | Name | Type | Traffic direction | # of lanes | Barangays | Notes |
| Acacia Lane | Tertiary | two-way | 2–4 | Hagdang Bato Libis and Addition Hills | Also known as Welfareville Road. Road terminates at Shaw Boulevard in the north and loops around the Welfareville Compound in the south. |
| A. Bonifacio Road | Tertiary | two-way | 2 | Mabini-J. Rizal and Hagdang Bato Itaas | |
| A. Luna Road | Tertiary | two-way | 2 | Hagdang Bato Itaas and Hagdang Bato Libis | |
| Barangka Drive | Tertiary | one-way, two-way | 2 | Highway Hills, Mauway, Barangka Itaas, Barangka Ibaba, Hulo | Road continues as Domingo M. Guevara Street in the north. Leads to Estrella–Pantaleon Bridge in the south. |
| Boni Avenue | Tertiary | two-way | 2–8 | Old Zañiga and Ilaya | Road continues as Rev. Aglipay Street in the west and as Pioneer Street in the east. |
| EDSA | Primary | two-way | 10–12 | Wack-Wack Greenhills | |
| F.B. Martinez Avenue | City Road | two-way | 4 | Pleasant Hills, Addition Hills, Plainview | |
| General Kalentong Street | Tertiary | two-way | 2–4 | Old Zañiga and Daang Bakal | Road continues as New Panaderos Extension and F. Roxas Street in the southwest and as F. Blumentritt Street in the northwest. |
| Luna Mencias Road | Tertiary | two-way | 2 | Addition Hills | Road terminates at P. Guevarra Street in the north and terminates at Shaw Boulevard in the south. |
| New Panaderos Extension | Tertiary | two-way | 4–6 | Mabini-J. Rizal and Namayan | Road continues northeast as General Kalentong Street |
| Nueve de Pebrero Street | Tertiary | two-way | 2–4 | Hagdang Bato Libis and Mauway | Also known as 9 de Febero Street and formerly known as Psychopathic Hospital Road. Road continues as Gomezville Street in the northwest and as Arayat Street in the east. |
| Ortigas Avenue | Primary | two-way | 6–8 | Wack-Wack Greenhills | |
| Pioneer Street | Tertiary | two-way | 4 | Ilaya | Road continues west as Boni Avenue and terminates at Shaw Boulevard in the northeast. |
| Shaw Boulevard | Secondary | two-way | 4–8 | Daang Bakal, Addition Hills, Highway Hills, Wack-Wack Greenhills East | Road continues as P. Sanchez Road in the west and continues as Pasig Boulevard in the east. |
| Route | Name | Type | Traffic direction | # of lanes | Barangays | Notes |
| A. Bonifacio Avenue | Secondary | two-way | 4 | Barangka, Tañong, Jesus Dela Peña | Road continues east as Sumulong Highway, and terminates at Marilaque Highway |
| Bagong Farmers Avenue 1 | Tertiary | two-way | 4 | Tumana | Road continues west as Katipunan Street Extension in Quezon City |
| Bayan-Bayanan Avenue | Tertiary | two-way | 4 | Concepcion Uno, Marikina Heights | Road continues east as Liwasang Kalayaan Circle Road |
| FVR Road | Primary | two-way | 6-8 | Industrial Valley Complex | Known as C5 Access Road, road continues south as Eulogio Rodriguez Jr. Avenue in Quezon City |
| General Ordoñez Avenue | Tertiary | two-way | 2-4 | Marikina Heights | Formerly known as Molave Street; a type of ring road |
| J.P. Rizal Street | Secondary | two-way | 2-4 | Calumpang, San Roque, Santa Elena, Santo Niño, Malanday, Concepcion Uno, Nangka | Road continues north as General Luna Avenue in San Mateo, Rizal |
| Katipunan Street | Tertiary | two-way | 2 | Concepcion Uno, Concepcion Dos, Marikina Heights | Road continues south in Cainta, Rizal |
| Lilac Street | Tertiary | two-way | 2 | Concepcion Dos | Road continues south as Hon. B. Soliven Avenue in Antipolo, Rizal |
| Marikina–Infanta Highway | Primary | two-way | 8-10 | Barangka, Calumpang, San Roque | Known as Marilaque Highway and Marcos Highway |
| Mayor Gil Fernando Avenue | Secondary | two-way | 4 | San Roque, Santa Elena, Santo Niño | Formerly known as Angel Tuazon Avenue; road continues south as Felix Avenue in Cainta, Rizal |
| Shoe Avenue | Tertiary | two-way | 4 | San Roque, Santa Elena, Santo Niño | Formerly the line of old train tracks of PNR Rosario-Montalban branch; road continues north as Daang Bakal Road |
| Sumulong Highway | Secondary | two-way | 6 | Santo Niño | Road continues west as A. Bonifacio Avenue |
| Route | Name | Traffic direction | # of lanes | Barangays | Notes |
| A. Luna Avenue | | | San Nicolas and San Joaquin | Road continues as A. Mabini Street. |
| ADB Avenue | two-way | 4–6 | San Antonio and Ugong | |
| Lopez Jaena Street | two-way | 2–4 | Caniogan and Kapasigan | |
| Cipriano Raymundo Avenue | two-way | | Santa Lucia and Kapasigan | Road continues as Tramo Street |
| Dr. Sixto Antonio Avenue | two-way | | Santa Lucia and San Nicolas | |
| East Bank Road | two-way | | Manggahan and Santa Lucia | |
| Eulogio Amang Rodriguez Avenue | two-way | 4 | Santolan and Santa Lucia | |
| Eulogio Rodriguez Jr. Avenue | two-way | 8–10 | Ugong and Bagong Ilog | Road continues south as Carlos P. Garcia Avenue |
| Julia Vargas Avenue | one-way, two-way | 4–6 | San Antonio and Ugong | Road starts from EDSA and ends at Eulogio Rodriguez Jr. Avenue |
| Lanuza Avenue | two-way | 4–6 | Ugong | |
| Meralco Avenue | two-way | 4–8 | Ugong and San Antonio | |
| Ortigas Avenue | two-way | 6–8 | Ugong, Santa Lucia, and Rosario | Road continues east as Corazon C. Aquino Avenue in Taytay, Rizal |
| Pasig Boulevard | two-way | 4 | Bagong Ilog and Sagad | Road is a continuation of Shaw Boulevard. |
| Pioneer Street | two-way | 4 | Kapitolyo | |
| San Miguel Avenue | two-way | 6 | San Antonio | |
| Shaw Boulevard | two-way | 4–8 | | Road continues as Pasig Boulevard. |
| West Bank Road | two-way | | Manggahan and Santa Lucia | |
| Route | Name | Traffic direction | # of lanes | Barangays | Notes |
| Aurora Boulevard | two-way | 4 | Ermitaño, Balong-Bato, Salapan | |
| EDSA | two-way | 8–10 | Greenhills | |
| F. Blumentritt Street | two-way | 2–4 | Rivera, San Perfecto, Pedro Cruz, Batis, Tibagan, Kabayanan | Road continues as General Kalentong Street. |
| F. Manalo Street | two-way | 2 | Onse, Santa Lucia, Maytunas, Kabayanan, Batis, San Perfecto | |
| Gregorio Araneta Avenue | two-way | 6–8 | Progreso | |
| Luna-Mencias Street | one-way | 2 | Addition Hills | |
| M.J. Paterno Street | two-way | 2 | Pasadeña | |
| N. Domingo Street | two-way | 2–4 | Progreso, San Perfecto, Rivera, Pedro Cruz, Balong-Bato, Corazon de Jesus, Ermitaño, Pasadeña | Road continues west as Old Santa Mesa Road. |
| Ortigas Avenue | two-way | 4–8 | Greenhills | Road continues west as Granada Street. |
| Pedro Guevarra Street | one-way, two-way | 2 | Maytunas, Addition Hills, Santa Lucia, Little Baguio, St. Joseph, Corazon De Jesus | |
| Pinaglabanan Street | two-way | 2–6 | Pedro Cruz, Balong-Bato, Corazon de Jesus | Road continues as Bonny Serrano Avenue. |
| Route | Name | Designation | Barangays | Notes |
| Amorsolo Street | national tertiary road | Pio del Pilar, San Lorenzo, Dasmariñas | |
| Arnaiz Avenue | national tertiary road | San Lorenzo, Bangkal, Pio del Pilar | |
| Ayala Avenue | private road | San Lorenzo, Urdaneta, Bel-Air, San Antonio, Pio del Pilar | |
| Chino Roces Avenue | national tertiary road | Dasmariñas, La Paz, Olympia, Pio del Pilar, San Antonio, Bangkal, Tejeros | |
| EDSA | national primary road | Guadalupe VIejo, Guadalupe Nuevo, Bel-Air, Pinagkaisahan, Urdaneta, Forbes Park, San Lorenzo, Dasmariñas, Bangkal, Magallanes | |
| Estrella Street | national tertiary road | Bel-Air, Poblacion, Guadalupe Viejo | |
| Gil Puyat Avenue | national secondary road | Bel-Air, Palanan, Pio del Pilar, San Antonio, San Lorenzo, Urdaneta | |
| Jose P. Rizal Avenue | national tertiary road | Guadalupe Nuevo, Guadalupe Viejo, Poblacion, Valenzuela, Olympia, Tejeros | |
| Kalayaan Avenue | national tertiary road | Singkamas to Poblacion in Makati and Pinagkaisahan to Guadalupe Nuevo, with a short span of the avenue entering Pitogo, Taguig before its reentry again to Makati | |
| McKinley Road | national tertiary road | Dasmariñas, Forbes Park | |
| Makati Avenue | private road, national tertiary road | San Lorenzo, Urdaneta, Bel-Air, Poblacion | |
| Nicanor Garcia Street | city road | Bel-Air, Valenzuela, Poblacion | |
| Osmeña Highway | national secondary road | Palanan, San Isidro, Pio del Pilar, Bangkal, San Lorenzo | |
| Paseo de Roxas | private road | San Lorenzo, Bel-Air, Urdaneta | |
| South Avenue | national tertiary road | Santa Cruz, Olympia | |
| Route | Name | Type | Traffic direction | # of lanes | Barangays / districts | Notes |
| 5th Avenue | | two-way one way | 4–6 | Bonifacio Global City | Road continues south as Lawton Avenue |
| 8th Avenue | | two-way one way | 2–6 | Bonifacio Global City | Road continues north as Lawton Avenue in Post Proper Northside while it continues south as Justicia Drive; A small disconnected segment of 8th Avenue is located starting at Manila American Cemetery up to McKinley Parkway |
| 11th Avenue | | two-way | 4–6 | Bonifacio Global City | |
| 26th Street | | two-way | 4–6 | Bonifacio Global City | Road continues east as Target Street in barangay Pembo |
| 32nd Street | | two-way | 4–8 | Bonifacio Global City | Connects EDSA and Carlos P. Garcia Avenue |
| 38th Street | | two-way | 4–6 | Bonifacio Global City | Road continues east as University Parkway |
| Arca Boulevard | | two-way | 4–5 | Arca South | |
| Bagong Calzada Street | Tertiary | two-way | 2 | Santa Ana, Tuktukan and Ususan | Diversion road; connects M. Almeda Street in Pateros to Gen. Luna Street in barangay Santa Ana, Taguig |
| Bayani Road | | two-way | 4–6 | Western Bicutan | Road continues south as the Maria Rodriguez Tinga Avenue |
| Cayetano Boulevard | | two-way | 4–6 | Calzada-Tipas, Ligid-Tipas, Palingon-Tipas and Ususan | Road continues north as Visitacion Street |
| Carlos P. Garcia Avenue | Primary | two-way | 6–8 | East Rembo, Fort Bonifacio, Pembo, Pinagsama, Rizal, Ususan, West Rembo and Western Bicutan | |
| General Luna Street | Secondary | two-way | 2 | Santa Ana, Tuktukan and Ususan | Road continues north as M. Almeda Street in Pateros |
| General Santos Avenue | Secondary | two-way | 4-6 | Central Bicutan, Lower Bicutan and North Daang Hari | Road continues west as Doña Soledad Avenue in Parañaque while it continues east as the Circumferential Road 6 |
| J. P. Rizal Avenue Extension | Tertiary | two-way | 4 | Cembo, Comembo, East Rembo and West Rembo | Road continues east as B. Morcilla Street in Pateros |
| Kalayaan Avenue | Secondary | two-way | 4-8 | Cembo, Comembo, East Rembo and West Rembo | Road continues east as San Guillermo Avenue upon crossing Buting Bridge in Buting, Pasig |
| Lawton Avenue | Tertiary | two-way | 4-6 | Cembo, Fort Bonifacio, Pinagsama, Post Proper Northside and Western Bicutan | A small disconnected segment traverses Cembo and Post Proper Northside which continues south as the 8th Avenue in Bonifacio Global City |
| Le Grande Avenue | | two-way | 4 | Bonifacio Capital District | |
| McKinley Parkway | | two-way | 6 | Bonifacio Global City | Road continues north as University Parkway, while the road continues west as McKinley Road in Forbes Park, Makati |
| McKinley Road | | two-way | 4 | Bonifacio Global City | A short portion is inside Bonifacio Global City while the rest of the road is in Makati; serves as an access road towards BGC |
| Maria Rodriguez Tiñga Avenue | | two-way | 2-4 | Central Signal Village, Hagonoy, New Lower Bicutan, North Signal Village and Pinagsama | |
| Manuel L. Quezon Street | Secondary | two-way | 2-4 | Bagumbayan, Bambang, Hagonoy, Lower Bicutan, New Lower Bicutan, San Miguel, Tuktukan and Wawa | |