RDS
- Amazon Relational Database Service
- Australian Research Data Commons
- RDS Arena
- RDS Info
- RTS (TV station)
- Radio Data System
- Radio Dimensione Suono
- Rajolibanda Diversion Scheme
- Random dot stereogram
- Rate-determining step
- Red dot sight
- Reddish South railway station
- Reflectance difference spectroscopy
- Relational developmental systems
- Reliable Datagram Sockets
- Remote Desktop Services
- Respiratory distress syndrome (disambiguation)
- Respondent-driven sampling
- Retiree Drug Subsidy
- Reward deficiency syndrome
- Romania Data Systems
- Royal Dublin Society
- Réseau des sports
- Shell plc
- Soviet atomic bomb project