Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling
Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling is a scholarly work by Yibin Kang, published in 2010 in ''Journal of Biological Chemistry''. The main subjects of the publication include gene knockdown, regulator, biology, Hes3 signaling axis, CDK8, osteoclast, Notch proteins, cell biology, signal transduction, HES1, cell signaling, Notch signaling pathway, Mediterranean Sea, and cell fate determination. The authors show that Rabconnectin-3B is required for the Notch pathway in mammalian cells. siRNA-mediated silencing of Rabconnectin-3B in mammalian cells attenuated Notch signaling and disrupted the activation and nuclear accumulation of the Notch target Hes1.