RW-93
RW-93 is a drug which acts as a potent and selective sirtuin 2 inhibitor. It inhibits SIRT2 with an IC50 of 15.5nM, and is highly selective over SIRT1, SIRT3 and SIRT5, however its activity has not been reported at SIRT4, SIRT6 or SIRT7. It was developed to assist with research into the role of SIRT2 in degenerative diseases such as Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, and multiple sclerosis.