RU-28253

RU-28253, also known as 5-MeO-THPI, is a non-selective serotonin [receptor agonist] of the tryptamine, 5-methoxytryptamine, and tetrahydropyridinylindole families. It is a tetrahydropyridylindole and a conformationally constrained analogue of 5-MeO-DMT.
The drug shows high affinity for the serotonin 5-HT_1A receptor and lower affinity for the serotonin 5-HT_2A receptor. Its affinities for these receptors were higher than those of dimethyltryptamine. RU-28253 is described as a potent agonist of the serotonin 5-HT₁ and 5-HT₂ receptors, including of the serotonin 5-HT_1B receptor, and is also an agonist of the serotonin 5-HT₄ receptor.
RU-28253 was first described in the scientific literature by 1983.