RTIOX-276
RTIOX-276 is an orexin antagonist. RTIOX-276 binds selectively to the orexin 1 receptor and lacks significant affinity for the orexin 2 receptor. RTIOX-276 may have therapeutic utility for the treatment of cocaine addiction. In conditioned place preference studies, RTIOX-276 attenuated the development of place preference in mice exposed to cocaine.