RSE
- Békéscsabai RSE
- Guitar Pro
- Odakyu 20000 series RSE
- Pokémon
- Pokémon Emerald
- Pokémon Ruby and Sapphire
- RSE Kriens
- RSE Kriens (missile)
- Ramtha's School of Enlightenment
- Red Seal Endorsement
- Red Storm Entertainment
- Refractory status epilepticus
- Relationship and Sex Education
- Relative standard error
- Rensselaer Society of Engineers
- Research software engineering
- Rhein-Sieg-Eisenbahn
- Rose Bay Water Airport
- Rosenberg self-esteem scale
- Royal Society of Edinburgh
- Rwanda Stock Exchange