RPF
- GIS file format
- Radioisotope Production Facility
- Railway Protection Force
- Rassemblement du Peuple Français
- Rassemblement pour la France
- Real person fiction
- Reformatorische Politieke Federatie
- Rehabilitation Project Force
- Reichspfenning (1924–1948)
- Renal plasma flow
- Retroperitoneal fibrosis
- Reverse power feeding
- Reverse-path forwarding
- Rohingya Patriotic Front
- Rwandan Patriotic Front