RO4491533
RO-4491533 is a drug developed by Hoffmann-La Roche which acts as a potent and selective negative [allosteric modulator] for Metabotropic glutamate receptor#Group [II and Group III|group II] of the metabotropic glutamate receptors, being equipotent at mGluR2 and mGluR3 but without activity at other mGluR subtypes. In animal studies, RO-4491533 produced antidepressant effects and reversed the effects of the mGluR2/3 agonist LY-379,268 with similar efficacy but slightly lower potency than the mGluR2/3 antagonist LY-341,495. A number of related compounds are known, with similar effects in vitro and a fairly well characterized structure-activity relationship.