RIMS1Regulating synaptic membrane exocytosis protein 1 is a protein that in humans is encoded by the RIMS1 gene.FunctionRAB3A, a member of the Ras superfamily of genes, is a synaptic vesicle protein that regulates synaptic vesicle exocytosis. MUNC13 and its isoforms are required for priming synaptic vesicles for exocytosis. The RIM family of active zone proteins likely function as protein scaffolds that help regulate vesicle exocytosis during short-term plasticity.Clinical significanceMutations of the gene cause cone-rod dystrophy 7.InteractionsRIMS1 has been shown to interact with: ERC2, RAB3A, UNC13A, UNC13B, and YWHAH.