RBM3
Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene.
Function
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. RBM3 contains a poison exon whose inclusion is lowered during hypothermia.RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects. According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues and based on confocal microscopy mainly localised to the nucleoplasm.