RASSF9


Ras association domain-containing protein 9, also known as PAM COOH-terminal interactor protein 1 or peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor is a protein that in humans is encoded by the RASSF9 gene.

Function

RASSF9 the N-terminal RASSF family member Ras association domain family member 9 12q21.31, is one of two new wild type RASSF9 and RASSF10 proteins. Three proteins that interact with a fragment of the PAM cytosolic domain containing signaling switch I and II the RA1 and RA2ras complex. RASSF7, the first member of the N-terminal RASSF family is required for mitosis. RASSF9 is recently found to be involved in regulation of epidermal homeostasis.

Regulation

The mutant proregion encoding PAM COOH-terminal interactor protein-1 is comparable to that of human band 4.1-like TF as a recycling endosomal pathway in microtubule locations, does NOT bind RasGTP. Specificity of interaction may all be related to microtubule locations of the endosomal-lysosomal system localized within the centrosome with Transferrin and different Ras proteins or with that one, but on the other hand, it interacts with three residues function, blocked by a mutation that affects Ras effector function is the critical product of the t (6:11) abnormality associated with some human leukemias. Phosphatidylinositol-3-kinase make contacts with both switch I and II regions of ras and yeast adenylyl cyclase molecules carrying these mutations are rendered unactivatable by Ras in vitro. Ras-interacting residues, are appreciably different from that of RalGDS-RBD through their C-terminal Ras-binding domains. Such outliers as afadin/AF-6 and Rin1 were found to inhibit the binding of Raf to Ras. Adenylyl cyclase molecules carrying these mutations are rendered unactivatable by Ras in vitro with the Ras-associating domain-RA, not all RA domains bind RasGTP it is a primary Ras-binding site.

Interactions

  • PAM Peptidyl-glycine alpha-amidating monooxygenase precursor
  • RASSF7 Ras association domain-containing protein 7
  • BLOC1S2 Biogenesis of lysosome-related organelles complex-1 subunit 2
  • TF Serotransferrin precursor
  • RAB11A Ras-related protein Rab-11A