ACE inhibitor and thiazide combination

An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension. They are given by mouth. ACE inhibitors reduce the activity of angiotensin-converting enzyme which produces angiotensin II, a hormone that constricts blood vessels. Thiazides are a class of diuretics that inhibit the thiazide receptor, thereby increasing urine production and reducing excess water and salt in the body. Several organizations recommend combination therapy for hypertension in cases of failure of a single drug to achieve target blood pressure, or even as a first line treatment for some patients.

Examples

Enalapril/hydrochlorothiazide, wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide.
Quinapril/hydrochlorothiazide
Lisinopril/hydrochlorothiazide is marketed as Prinzide, Zestoretic, and many others.

Fosinopril/hydrochlorothiazide

Fosinopril/hydrochlorothiazide has a boxed warning about its risk to cause morbidity and mortality in the baby when being used during pregnancy.
The FDA modified its labeling in February 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions have been reported rarely in patients on therapy with injectable gold and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."