Pyrinuron

Pyrinuron is a chemical compound formerly used as a rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the United [States Environmental Protection Agency|Environmental Protection Agency] for use in the United States. If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide by NAMPT and VMN's subsequent activation of the NADase SARM1.