Pyrimidine analogue

Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.

Examples

Nucleobase analogues
*Fluorouracil, which inhibits thymidylate synthase
*Floxuridine
*6-azauracil
Nucleoside analogues
*Cytarabine
*Gemcitabine
Nucleotide analogues

Medical uses

Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.