Primary cutaneous immunocytoma
Primary cutaneous immunocytoma was initially regarded as a distinct type of the cutaneous lymphomas of the skin. A 1997 review characterized 16 cases of primary cutaneious immunocytomo as skin lesions located on the arms and legs that in 15 of 16 cases had an excellent responses to, and prognoses after, purely local treatments. On microscopic histological examination, these lesions consisted of B cells and nodular or diffuse infiltrates of lymphoplasmacytoid-like plasma cells located at the periphery of these infiltrates. In 2004, however, the World Health Organization and European Organisation for Research and Treatment of Cancer classified primary cutaneous immunocytoma as one form of the primary cutaneous marginal zone lymphomas or, as they are now termed, primary cutaneous marginal zone lymphoproliferative disorders.