Polypoid melanomaPolypoid melanoma is a rare cutaneous condition, a virulent variant of nodular melanoma. Polypoid melanoma is a subtype of nodular melanoma, the most aggressive form of melanoma.Signs and symptomsPolypoid melanoma is distinguished by a profile that resembles cauliflower and an uneven surface.TreatmentTherapies for metastatic melanoma include the biological immunotherapy agents ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and an MEK inhibitor trametinib.