Poly(a) binding protein interacting protein 2b

Poly binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene.

Function

Most mRNAs, except for histones, contain a 3-prime poly tail. Poly-binding protein enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 and the poly tail. Various PABP-binding proteins regulate PABP activity, including PAIP1, a translational stimulator, and PAIP2A and PAIP2B, translational inhibitors..