PLC
- Colombian Liberal Party
- Conservative Party (Spain)
- Constitutionalist Liberal Party
- Liberal Party of Canada
- PL/C
- Packet loss concealment
- Palestinian Legislative Council
- Pennsylvania Leadership Conference
- Peptide loading complex
- Perlecan
- Peter Lougheed Centre
- Phi Life Cypher
- Phospholipase C
- Pine Lake Camp
- Pityriasis lichenoides chronica
- Platoon Leaders Class
- Polish–Lithuanian Commonwealth
- Portevin–Le Chatelier effect
- Portland Lesbian Choir
- Post Leaving Certificate
- Posterolateral corner
- Power-line communication
- Presbyterian Ladies' College (disambiguation)
- Presidential Leadership Council
- Prism Leisure Corporation
- Product lifecycle
- Professional learning community
- Programmable logic controller
- Provisional Legislative Council
- Public limited company
- UAE Pro League Committee