Pipecolic acid
Pipecolic acid is an organic compound with the formula HNC5H9CO2H. It is a carboxylic acid derivative of piperidine and, as such, an amino acid, although one not encoded genetically. Like many other α-amino acids, pipecolic acid is chiral, although the S-stereoisomer is more common. It is a colorless solid.
Its biosynthesis starts from lysine. CRYM, a taxon-specific protein that also binds thyroid hormones, is involved in the pipecolic acid pathway.
Medicine
It accumulates in pipecolic acidemia. Elevation of pipecolic acid can be associated with some forms of epilepsy, such as pyridoxine-dependent epilepsy.Occurrence and reactions
Like most amino acids, pipecolic acid is a chelating agent. One complex is Cu22.Pipecolic acid was identified in the Murchison meteorite.
It also occurs in the leaves of the genus Myroxylon, a tree from South America.