Percavirus


Percavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. Diseases associated with this genus include: conjunctivitis, immunosuppression in foals, pneumonia, respiratory disease.

Species

The genus consists of the following species:Percavirus equidgamma2, also called Equid gammaherpesvirus 2Percavirus equidgamma5, also called Equid gammaherpesvirus 5Percavirus felidgamma1, also called Felid gammaherpesvirus 1Percavirus mustelidgamma1, also called Mustelid gammaherpesvirus 1Percavirus phocidgamma3, also called Phocid gammaherpesvirus 3Percavirus rhinolophidgamma1Percavirus vespertilionidgamma1, also called Vespertilionid gammaherpesvirus 1

Structure

Viruses in Percavirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 180kb in length.
GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
PercavirusSpherical pleomorphicT=16EnvelopedLinearMonopartite

Life cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding.
Mammals serve as the natural host.
GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
PercavirusMammalsB-lymphocytesGlycoprotiensBuddingNucleusNucleusSex; saliva