Penstemon pruinosus usually grows tall, but may occasionally grow as tall as. The stems and basal leaves sprout from a stout branched woody base. At the base of the plant, the elliptic to ovate leaves may be up long and wide and born on long petioles. The flowering stem also has pairs of similar but smaller leaves that lack a petiole and clasp the stem. Both types of leaves usually have many small sharp teeth, but sometimes the teeth are obscure or missing on some leaves. The stem, flower calyx, and bases of the petals have short glandular hairs, but the leaves can be either glandular, hairy, or glabrous. The tubular blue flowers are born in separated whorls and are marked with lines on the lower part of the throat. The petals' lobes vary from pale to deep blue and basal to the lobes the color often has a purple to violet tone.
Penstemon pruinosus is found in open areas in central Washington and south-central British Columbia in a variety of open habitats from lower elevations to low mountains. It grows in arid habitats with sagebrush or pine trees from.