The genus was erected by Leopold Fitzinger in 1843, but placed in synonymy with Bufo by Albert Günther in 1859. Subsequent work has considered Peltophryne either as a valid genus, a subgenus, or a synonym of Bufo. At present, treatingPeltophryne as a valid genus has largely been accepted based on both morphological characters and genetic evidence, but treating it as a subgenus of Bufo still has a small following.