Fred Payne

• Fred Payne (baseball), Major League Baseball player for the Detroit Tigers and Chicago White Sox
• Frederick Payne of the Payne Brothers pantomime act
• Frederick G. Payne, U.S. politician
• Frederick Huff Payne, United States Assistant Secretary of War
• Fred Payne (footballer), Australian rules footballer
• Fred Payne (actor), British actor in Nuts and Wine
• Frederick Payne (umpire), South African cricket umpire
• Frederick R. Payne Jr., American Marine Corps general